The demand for urban transport: An application of discrete choice model for Cadiz

The study of the demand for transport has among others applications, the valuation of travel time saving that is a very important question in cost-benefit analysis, and to adopt transport policy tools. Since McFadden developed a discrete choice model for travel demand, it has usually been the application of this model to study the individual behaviour when he has to choice among transport modes. Citizens of big cities have to face traffic congestion; pollution, wasted time in travels and fuel, noise, stress and accidents are the costs imposed by congestion to society, elements that reduce the quality of life in cities. Public transport is a real alternative to private transport that is socially less expensive, for this reason this paper tries to forecast travel demand for public transport in Cadiz when travelling have to choice between public or private transport, using a discrete choice model. The results of this analysis (travel demand, value of time, elasticities) can be used to design transport policies that could reduce congestion.

Bregman Proximal Gradient Algorithm with Extrapolation for a class of Nonconvex Nonsmooth Minimization Problems

In this paper, we consider an accelerated method for solving nonconvex and nonsmooth minimization problems. We propose a Bregman Proximal Gradient algorithm with extrapolation(BPGe). This algorithm extends and accelerates the Bregman Proximal Gradient algorithm (BPG), which circumvents the restrictive global Lipschitz gradient continuity assumption needed in Proximal Gradient algorithms (PG). The BPGe algorithm has higher generality than the recently introduced Proximal Gradient algorithm with extrapolation(PGe), and besides, due to the extrapolation step, BPGe converges faster than BPG algorithm. Analyzing the convergence, we prove that any limit point of the sequence generated by BPGe is a stationary point of the problem by choosing parameters properly. Besides, assuming Kurdyka-{\'L}ojasiewicz property, we prove the whole sequences generated by BPGe converges to a stationary point. Finally, to illustrate the potential of the new method BPGe, we apply it to two important practical problems that arise in many fundamental applications (and that not satisfy global Lipschitz gradient continuity assumption): Poisson linear inverse problems and quadratic inverse problems. In the tests the accelerated BPGe algorithm shows faster convergence results, giving an interesting new algorithm.Comment: Preprint submitted for publication, February 14, 201

Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture

Malnutrition is very prevalent in geriatric patients with hip fracture. Nevertheless, its importance is not fully recognized. The objective of this paper is to review the impact of malnutrition and of nutritional treatment upon outcomes and mortality in older people with hip fracture. We searched the PubMed database for studies evaluating nutritional aspects in people aged 70 years and over with hip fracture. The total number of studies included in the review was 44, which analyzed 26,281 subjects (73.5% women, 83.6 ± 7.2 years old). Older people with hip fracture presented an inadequate nutrient intake for their requirements, which caused deterioration in their already compromised nutritional status. The prevalence of malnutrition was approximately 18.7% using the Mini-Nutritional Assessment (MNA) (large or short form) as a diagnostic tool, but the prevalence was greater (45.7%) if different criteria were used (such as Body Mass Index (BMI), weight loss, or albumin concentration). Low scores in anthropometric indices were associated with a higher prevalence of complications during hospitalization and with a worse functional recovery. Despite improvements in the treatment of geriatric patients with hip fracture, mortality was still unacceptably high (30% within 1 year and up to 40% within 3 years). Malnutrition was associated with an increase in mortality. Nutritional intervention was cost effective and was associated with an improvement in nutritional status and a greater functional recovery. To conclude, in older people, the prevention of malnutrition and an early nutritional intervention can improve recovery following a hip fracture

Tracing out the Northern Tidal Stream of the Sagittarius Dwarf Spheoridal Galaxy

The main aim of this paper is to report two new detections of tidal debris in the northern stream of the Sagittarius dwarf galaxy located at 45 arcdeg and 55 arcdeg from the center of galaxy. Our observational approach is based on deep color-magnitude diagrams, that provides accurate distances, surface brightness and the properties of stellar population of the studied region of this tidal stream. The derived distances for these tidal debris wraps are 45 kpc and 54 kpc respectively.We also confirm these detections with numerical simulations of the Sagittarius dwarf plus the Milky Way. The model reproduces the present position and velocity of the Sagittarius main body and presents a long tidal stream formed by tidal interaction with the Milky Way potential. This model is also in good agreement with the available observations of the Sagittarius tidal stream. We also present a method for estimating the shape of the Milky Way halo potential using numerical simulations. From our simulations we obtain an oblateness of the Milky Way dark halo potential of 0.85, using the current database of distances and radial velocities of the Sagittarius tidal stream. The color-magnitude diagram of the apocenter of Sagittarius shows that this region of the stream shares the complex star formation history observed in the main body of the galaxy. We present the first evidence for a gradient in the stellar population along the stream, possibly correlated with its different pericenter passages. (abridged)Comment: 43 pages (including 15 figures; for high resolution color figures, please contact [email protected]). Submitted to Ap

Evaluación de conocimientos básicos de estadística en ingenierías agroforestales de la Universidad Politécnica de Madrid.

Evaluación de conocimientos básicos de estadística en ingenierías agroforestales de la Universidad Politécnica de Madrid

Diseño de un cuestionario para evaluar conocimientos básicos de estadística de estudiantes del último curso de ingeniería

Se presenta la elaboración de un cuestionariopara evaluar conocimientos básicos de estadística para estudiantes de ingeniería. El cuestionario original incluyó un amplio número de ítems agrupados por bloques temáticos. Este se propuso a un panel de expertos, formado por nueve profesores de la asignatura de Estadística Aplicada de distintas titulaciones de ingeniería en universidades iberoamericanas

A genome-wide 20 K citrus microarray for gene expression analysis

<p>Abstract</p> <p>Background</p> <p>Understanding of genetic elements that contribute to key aspects of citrus biology will impact future improvements in this economically important crop. Global gene expression analysis demands microarray platforms with a high genome coverage. In the last years, genome-wide EST collections have been generated in citrus, opening the possibility to create new tools for functional genomics in this crop plant.</p> <p>Results</p> <p>We have designed and constructed a publicly available genome-wide cDNA microarray that include 21,081 putative unigenes of citrus. As a functional companion to the microarray, a web-browsable database <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> was created and populated with information about the unigenes represented in the microarray, including cDNA libraries, isolated clones, raw and processed nucleotide and protein sequences, and results of all the structural and functional annotation of the unigenes, like general description, BLAST hits, putative Arabidopsis orthologs, microsatellites, putative SNPs, GO classification and PFAM domains. We have performed a Gene Ontology comparison with the full set of Arabidopsis proteins to estimate the genome coverage of the microarray. We have also performed microarray hybridizations to check its usability.</p> <p>Conclusion</p> <p>This new cDNA microarray replaces the first 7K microarray generated two years ago and allows gene expression analysis at a more global scale. We have followed a rational design to minimize cross-hybridization while maintaining its utility for different citrus species. Furthermore, we also provide access to a website with full structural and functional annotation of the unigenes represented in the microarray, along with the ability to use this site to directly perform gene expression analysis using standard tools at different publicly available servers. Furthermore, we show how this microarray offers a good representation of the citrus genome and present the usefulness of this genomic tool for global studies in citrus by using it to catalogue genes expressed in citrus globular embryos.</p

Earthworm management in tropical agroecosystems

Data of 145 and 69 earthworm communities from managed and natural ecosystems, respectively, of four continents and 15 tropical countries were analysed. The aim of the study was to separate the influence of phylogenetic, environmental and agricultural factors on the structure of earthworm communities in agroecosystems, and to evaluate their relative importance in the whole soil macrofauna community. Earthworms comprise 40-90% of macrofaunal biomass in most ecosystems except for annually cropped systems. Three major conclusions were drawn from the analysis of community structure (regional analysis) : (i) crops were, independently of region, characterized by a loss of native species and by the dominance of exotic endogeics ; (ii) pastures were highly heterogenous in terms of native or exotic species dominance ; (iii) native species survived better in management ecosystems of India and Africa than in Mexico-Central America. Local analysis in selected countries indicated that, as a general rule, the intensity of agricultural practices is negatively correlated with the amount of native species and the total abundance and biomass of earthworms ; the only exception was found in the conversion of savannas to pastures, in Colombian llanos. (Résumé d'auteur

In vitro Validation of Quantitative Light-Induced Fluorescence for the Diagnosis of Enamel Fluorosis in Permanent Teeth

This study aimed to validate quantitative light-induced fluorescence (QLF) as a diagnostic tool for mild and moderate enamel fluorosis in permanent teeth, comparing it to visual diagnosis and histological assessment completed using polarized light microscopy (PLM). The buccal surfaces of 139 teeth were visually classified using the Thylstrup and Fejerskov Index (TFI) into sound (TFI 0; n = 17), mild (TFI 1-2; n = 69), and moderate (TFI 3-4; n = 43) fluorosis. Fluorosis was then assessed with QLF (variables ΔF, A, and ΔQ at 5-, 15-, and 30-radiance thresholds) using as reference areas the entire surface and a region of interest (ROI), identified as the most representative region of a fluorosis lesion. PLM images of longitudinal thin sections including the ROI were assessed for histological changes. Correlations among TFI, PLM, and QLF were determined. A receiver-operating characteristic curve was conducted to determine QLF's diagnostic accuracy when compared to the TFI and PLM assessments. This was used to assess the probability that the images were correctly ranked according to severity as determined by PLM and TFI. A positive correlation was found between QLF and PLM, and between QLF and TFI. QLF showed the highest sensitivity and specificity for the diagnosis of mild fluorosis. There was also a strong agreement between TFI and PLM. The selection of a ROI resulted in a stronger correlation with TFI and PLM than when the entire surface was used. The study results indicate that defining an ROI for QLF assessments is a valid method for the diagnosis of mild and moderate enamel fluorosis

Impact of the COVID-19 pandemic on the care of cancer patients in Spain

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Càncer; EspanyaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Cáncer; EspañaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Cancer; SpainBackground Studies evaluating the effects of the COVID-19 pandemic on public healthcare systems are limited, particularly in cancer management. As no such studies have been carried out in Spain, our objective is to describe and quantify the impact of the COVID-19 pandemic on cancer patients in Spanish hospitals during the first wave of the pandemic. Materials and methods This retrospective, multicenter, nationwide study collected information from hospital departments treating oncology patients. An electronic questionnaire comparing outcomes and management of oncohematological patients for the March-June 2019 and March-June 2020 periods was used. Results Information from 78 departments (36 tertiary hospitals) was analyzed. Forty-four departments implemented adapted protocols during March 2020. Most of these (n = 38/44; 86.4%) carried out COVID-19 triage, while 26 of 44 (59.1%) carried out onsite polymerase chain reaction tests for clinically suspected cases. A shift from in-person to telephone visits was observed in 43 of 44 (97.7%) departments. Comparing the March-June 2019 and March-June 2020 periods, the number of new patients decreased by 20.8% (from 160.2 to 126.4). Decreases were also seen in the mean number of total (2858.2 versus 1686.1) and cancer (465.5 versus 367.2) biopsies, as well as the mean number of bone marrow biopsies (30.5 versus 18.6). Concerning the number of patients visiting specific cancer care departments, a decrease from 2019 to 2020 was seen for mean number of chemotherapy treatments (712.7 versus 643.8) and radiation therapy (2169.9 versus 2139.9). Finally, a reduction from 2019 to 2020 of 12.9% (from 8.6 to 7.4) in the mean number of patients included in clinical trials was noted. Conclusions This study provides the first comprehensive data concerning the impact of COVID-19 on cancer care in Spain. The pandemic caused a 20.8% decrease in newly diagnosed patients, which may impact future outcomes. Measures must be taken to ensure cancer management receives priority in times of healthcare emergencies.This work was supported by funding from the AECC, a non-profit organization, whose medical department funded the study and the medical writing (no grant number)